ABSTRACT
ABSTRACT Myracrodruon urundeuva is a plant native to Brazil, which is used by the indigenous population for the treatment of candidiasis. The aims of this study were to evaluate the antifungal activity of extract against human vaginal Candida species and evaluate the possible toxicological activities of M. urundeuva. Initially, ethanol extracts, ethyl acetate fractions, and hydroalcoholic fractions of the bark and leaf of M. urundeuva were used to determine the minimum inhibitory concentration. The extracts that showed antifungal activity were characterized by liquid chromatography and subjected to toxicity assessment. Toxic, cytotoxic, genotoxic, and mutagenic testing were performed using Allium cepa and Ames assays with the ethanol extracts of the bark and leaves. Hemolytic activity was evaluated in erythrocytes and acute toxicity in rats. The ethanol bark extracts showed best activity against Candida albicans, C. krusei, and C. tropicalis ATCC (4-512 µg/mL). Chemical characterization indicated the presence of flavonoids and tannins in the extracts. Hemolytic activity, genotoxicity, and mutagenicity were not observed. The results of the Ames and A. cepa tests were also in agreement, ethanol bark extracts and ethanol leaf extracts of M. urundeuva showed absence of mutagenic activity. Similar results were observed in the A. cepa assay and acute toxicity test in rats. M. urundeuva bark extracts showed potential for the treatment of vaginal infections caused Candida species, as a topical.
Subject(s)
Humans , Animals , Female , Rats , Candida albicans/drug effects , Plant Extracts/pharmacology , Plant Leaves/chemistry , Anacardiaceae/chemistry , Antifungal Agents/pharmacology , Tannins/pharmacology , Flavonoids/pharmacology , Brazil , Microbial Sensitivity Tests , Plant Bark/chemistry , Antifungal Agents/isolation & purificationABSTRACT
The academic interest regarding the knowledge that people in general have about plants and their uses has increased significantly. Therefore, aiming to understand it better, this present work studied parts of the plant used by residents from Jardim Aeroporto, in Ponta Porã, Mato Grosso do Sul State, to prepare and use these medicinal plants. This city shares borders with Pedro Juan Caballero (Paraguay), a place where many people use these herbs. The residents use different kinds of plants which are planted around their houses. The leaf was the most used part to prepare the medicines. The plants used by this community belong to 17 families, 28 genera and 30 species, and the women from 30-40 age group with junior high school degree who know the plants, their usage and the preparation of the medicines. These women are responsible to cultivate the plants in the backyards and around their houses. The botanical families which presented higher number of species were Lamiaceae, Asteraceae and Leguminosae. Baccharis trimera (Less). DC., Mentha piperita L. and Aloe vera (L.) Burm. f. were the most used plants by the interviewees, which were prepared in form of tea or plasters.
O interesse acadêmico a respeito do conhecimento que as populações detêm sobre plantas e seus usos têm crescido. Visando conhecer melhor esse conhecimento, o presente trabalho objetivou: levantar o perfil dos usuários de plantas medicinais, caracterizar o conhecimento acercado uso de plantas medicinais, detectar as partes da planta mais empregadas no preparo e aplicação medicinal pela comunidade de moradores do Bairro Jardim Aeroporto em Ponta Porã, Estadodo Mato Grosso do Sul. Foram entrevistados 200 moradores, no período de julho a outubro de 2006. As entrevistas foram feitas pelo método da ?listagem livre?. A cidade faz divisa com Pedro Juan Caballero (Paraguai), onde muitas pessoas recebem as espécies medicinais. Os moradores fazem uso de grupo diversificado de plantas, presentes ao redor de suas casas. A parte vegetal mais citada como utilizada na preparação dos remédios foi a folha. As plantas utilizadas pela populaçãopertencem a 17 famílias, 28 gêneros e 30 espécies, e o conhecimento das plantas, uso e preparo é pertencente às mulheres, na faixa etária dos 30 a 40 anos, em sua maioria com grau de escolaridade do Ensino Fundamental. As mulheres são responsáveis pelo cultivo das plantas, emseus quintais ou ao redor de suas residências. As famílias botânicas que apresentaram maior número de espécies foram, respectivamente, Lamiaceae, Asteraceae e Leguminosae. Baccharis trimera (Less). DC (carqueja), Mentha piperita L. (hortelã) e Aloe vera (L.) Burm. f. (babosa) foram as plantas mais utilizadas pelos entrevistados, sendo preparadas na forma de chás ou emplastro.
Subject(s)
Humans , Ethnobotany , Ethnopharmacology , Plants, MedicinalABSTRACT
The academic interest regarding the knowledge that people in general have about plants and their uses has increased significantly. Therefore, aiming to understand it better, this present work studied parts of the plant used by residents from Jardim Aeroporto, in Ponta Porã, Mato Grosso do Sul State, to prepare and use these medicinal plants. This city shares borders with Pedro Juan Caballero (Paraguay), a place where many people use these herbs. The residents use different kinds of plants which are planted around their houses. The leaf was the most used part to prepare the medicines. The plants used by this community belong to 17 families, 28 genera and 30 species, and the women from 30-40 age group with junior high school degree who know the plants, their usage and the preparation of the medicines. These women are responsible to cultivate the plants in the backyards and around their houses. The botanical families which presented higher number of species were Lamiaceae, Asteraceae and Leguminosae. Baccharis trimera (Less). DC., Mentha piperita L. and Aloe vera (L.) Burm. f. were the most used plants by the interviewees, which were prepared in form of tea or plasters.
The academic interest regarding the knowledge that people in general have about plants and their uses has increased significantly. Therefore, aiming to understand it better, this present work studied parts of the plant used by residents from Jardim Aeroporto, in Ponta Porã, Mato Grosso do Sul State, to prepare and use these medicinal plants. This city shares borders with Pedro Juan Caballero (Paraguay), a place where many people use these herbs. The residents use different kinds of plants which are planted around their houses. The leaf was the most used part to prepare the medicines. The plants used by this community belong to 17 families, 28 genera and 30 species, and the women from 30-40 age group with junior high school degree who know the plants, their usage and the preparation of the medicines. These women are responsible to cultivate the plants in the backyards and around their houses. The botanical families which presented higher number of species were Lamiaceae, Asteraceae and Leguminosae. Baccharis trimera (Less). DC., Mentha piperita L. and Aloe vera (L.) Burm. f. were the most used plants by the interviewees, which were prepared in form of tea or plasters.